New York Yankees vs. Pittsburgh Pirates Preview, Prediction & Odds | April 5, 2025

This New York Yankees vs. Pittsburgh Pirates Preview will look at Game 2 on Saturday in the Bronx. In Game 1 on Friday, the Bronx Bombers defeated the Pirates, 9-4, as Aaron Judge hit another home run. Last season, the Yankees lost two of three to Pittsburgh. Let’s take a look at the starting pitchers, the stats, the series, and general trends, and offer up a pick on this Interleague game.

Yankees vs. Pirates Odds

Yankees vs. Pirates Game Details

• Game: New York Yankees at Pittsburgh Pirates

• Date and Time: Saturday, April 5, 2025, 7:05 EDT/6:05 CDT/4:05 PDT

• Location: PNC Park (Kentucky Bluegrass), Pittsburgh, Pennsylvania

Key Stats

New York Yankees

The Yankees are scheduled to start RHP Marcus Stroman (0-0, 5.79 ERA, 1.29 WHIP in 2025) in this series’ middle game in the Steel City. Stroman has been ineffective vs. the Pittsburgh Pirates lifetime, going 0-3 in five career appearances vs. the Bucs with a 3.52 ERA. The New York hitters haven’t seen much of Falter, with Jazz Chisholm Jr. (2-for-4, HR, 5 RBI), Tent Grisham (3-for-3, HR, 3 RBI), Paul Goldschmidt (.429), and Cody Bellinger (.300, 3 RBI) having some decent success. MLB HR leader Aaron Judge (6 HR)—who bashed his sixth of the season on Friday—hasn’t faced Falter yet.

Yankees Betting Trends

• New York has won 2 straight vs the Pirates (15 RF-8 RA)
• The Yankees have 22 HRs in their first 7 games (MLB-high) 
• New York has scored the most Runs in the AL (62)
• The Yankees were 23-23 in Interleague play last season (5-2 in 2025)
• The Over is 7-3-0 in the last 10 Yankees games (5-1-0 last 6)
• The Yankees were 21-23 vs LHP in the 2024 MLB Regular Season

Pittsburgh Pirates

The Pittsburgh Pirates are scheduled to start LHP Bailey Falter (0-0, 3.00 ERA, 1.17 WHIP in 2025) in this Home matinee on Saturday. In Game 1, Pittsburgh fell behind 7-1 and could never get enough going at the plate to close the gap. Both Ke’Bryan Hayes and Bryan Reynolds hit their first homers in the loss. Pittsburgh (-17 RD) is 2-5 on the Road and has only played this one Home game (Friday).

This series is usually dominated by the Yankees and we have seen high-scoring games the last three meetings (13, 10, and 13 Runs total). The leaders at the plate for the Pirates are Andrew McCutcheon (.375), Isaiah Kiner-Falefa (.360), Oneil Cruz (2 HR, 4 RBI), and Adam Frazier (5 Hits, 4 RBI).

Pirates Betting Trends

• Pittsburgh is 3-7 in the last 10 games in this series
• The Over is 7-2-1 in the last 10 games in the series
• The Over is 3-0-0 in the last 3 meetings
• Pittsburgh is 1-5 in its last 6 games overall
• The Under is 4-1-0 in the Pirates’ last 5 games
• The Pirates are 9-9 lifetime vs. the Yankees at Home

Prediction

The reason the money line betting is so low for the Yankees is that Stroman has struggled vs the Pirates (0-3) and because this game is being played in Pittsburgh. It’s a fair number and makes MLB Bettors think before blindly backing the Bronx Bombers. But going through each other’s lineups three (or more) times is the harsh reality for the hosts and the test here.

With Judge, Goldschmidt, Chisholm Jr., Bellinger, Anthony Volpe (4 HR, 9 RBI), Jasson Dominguez, Ben Rice, and others, the Pirates (.187 BA, #24 in MLB) will be outscored. The visitors are the side pick in this New York Yankees vs. Pittsburgh Pirates preview.

Final Pick

Yankees -144