Detroit Tigers vs. Chicago White Sox Preview, Prediction & Odds | April 4, 2025

This Detroit Tigers vs. Chicago White Sox Preview will look at Game 1 on Friday night of a three-game series in the Motor City. Last season, the Tigers went 10-3 in this AL Central series. This season, the AL Central is the land of two-win teams and a horrible combined record a week into the new season (10-21). Here, someone will have to win, so let’s take a look at the stats, trends, players, and metrics to make a free pick on this game.

White Sox vs. Tigers Odds

Chicago White Sox. vs Detroit Tigers Game Details

• Game: Chicago White Sox at Detroit Tigers

• Date and Time: Friday, April 4, 2025, 1:10 EDT/12:10 CDT/10:10 PDT

• Location: Comerica Park (Kentucky Bluegrass), Detroit, Michigan

Key Stats

Chicago White Sox

The White Sox are scheduled to start RHP Jonathan Cannon (5-10 4.49 ERA, 1.33 WHIP in 2024) in the series opener in Motown. Cannon is 1-2 lifetime vs Detroit with a 12.60 ERA and eight strikeouts in three appearances. Chicago is led at the plate by Andrew Benintendi (three HR, six RBI) and Brooks Baldwin (.357, 3 RBI), but beyond these two, no one else has really done much. The Pale Hose were 3-3 vs the Tigers in Detroit last season but 0-7 in Chicago. The dreadfully bad White Sox lost the first game of all three of those series.

White Sox Betting Trends

• Chicago has scored just four runs in its last two games
• This is the White Sox’s first Road game since September 29, 2024
• That last Road series was here in Detroit at Comerica Park
• Chicago has scored just six runs in its four losses
• The Over is 4-2-1 in the White Sox’s last seven games
• Chicago was 10-42 vs the AL Central last season

Detroit Tigers

The host Tigers are scheduled to start RHP Jack Flaherty (6-2 in 2024 with LAD). Flaherty has made 3 lifetime appearances vs the White Sox, going 1-1 with a 2.93 ERA and striking out 18. This will be the Tigers first Home game since October 10, 2024. Detroit was swept at Chavez Ravine by the Dodgers before winning 2 of 3 at Seattle. On offense, the Tigers are led by Spencer Torkelson (.318), Riley Greene (.296, 2 HR, 3 RBI), Dillon Dingler (5 RBI), and Manuel Margot (.385, 3 RB). It may be a little bit chilly at Comerica Park (45°) and remember the early first pitch time for this one.

Tigers Betting Trends

• The Tigers’ last seven games have all been on the Road
• Detroit went 10-3 against the White Sox last season
• The Tigers have lost two straight to Chicago in Detroit (5 RF-13 RA)
• Detroit is 2-6 in its last eight games overall, dating back to last year
• The Under is 4-2-0 in the last six series meetings in Detroit
• The Over is 6-2-0 in the last eight Tigers games overall

Prediction

The White Sox looked decent vs. the Twins but still managed to lose two out of three and finish its opening homestand at 2-4 before heading to Detroit for this 3-game series. In their last 16 MLB Home openers, the Tigers are 13-3, beating these White Sox in this spot in 2022. Cannon (0-0) did pretty well in his first time out, going 5.0 IP, allowing four hits, and walking three with five strikeouts.

With these two pitchers, the early start, the weather, and the cold bats for these two teams, runs may be scarce. But with Detroit doing so well last season vs. Chicago, sweeping all three Game 1’s, and doing well in Home openers, backing Flaherty and the host Tigers is the pick in this Detroit Tigers vs Chicago White Sox Preview.

Final Pick

Tigers -235