Minnesota Twins vs. Chicago White Sox Preview, Prediction and Odds | March 31, 2025

This Minnesota Twins vs. Chicago White Sox Preview will look at Game 1 on Monday afternoon of a 3-game series in Chicago. Last season, the Twins completely dominated this AL West series. But after a 0-3 start, will the visitors be desperate for a win? The Cardinals swept Minnesota, while Chicago won 8-1 on Opening Day before losing two 1-run games to the Angels in the Windy City.

Twins vs. White Sox Odds

Game Details

• Game: Minnesota Twins at Chicago White Sox

• Date and Time: Monday, March 31, 2025, 2:10 EDT/1:10 CDT/11:10 PDT

• Location: Rate Field (Kentucky Bluegrass), Chicago, Illinois

Key Stats

Minnesota Twins

The Twins are scheduled to start RHP Chris Paddack (5-2, 4.99 ERA, 1.39 WHIP in 2024). Paddack is 1-0 lifetime vs the White Sox in 2 starts with 13 strikeouts and a 1.50 ERA. His 2 ERs came here at Rate Field where he left after 5 IP and allowing just 3 hits. Minnesota was swept by the Cardinals in its opening series in St. Louis, being outscored 19-6 in the process.

SS Willi Castro leads the Twins in all offensive statistical categories so far. Castro has 1 HR, 3 RBI, 4 hits, a .400 Batting Average, and a .455 OBP. Players like Harrison Bader (.286) and Trevor Larnach (.300) have decent starts, but this team needs guys like Byron Buxton (1 hit), Ty France (1 hit), Matt Wallner (1 hit), and Carlos Correa (0 hits) to wake up.

Twins Betting Trends

• The Twins have scored just 6 runs in their first 3 games this MLB season
• Minnesota went 12-1 vs the White Sox last season
• The Twins have won 4 straight vs Chicago (32 RF-13 RA)
• Minnesota is 1-9 in its last 10 games overall, dating back to last year
• The Over is 7-3-0 in the Twins’ last 10 games

Chicago White Sox

The White Sox are scheduled to start LHP Martín Pérez (5-6, 4.53 ERA, 1.48 WHIP) in the series opener on the South Side. Pérez is 0-2 lifetime vs Minnesota with a 6.62 ERA and 22 strikeouts in 10 appearances, but none of those were with the Pale Hose. Despite scoring 8 runs on opening day and being above .500 for the first time in 2 years, Chicago has apparently returned to its anemic ways at the plate in Games 2 and 3 vs the Halos. 

Luis Robert (.250, 3 hits) and Andrew Benintendi (1 HR, 3 RBI) lead statistically, but the Yankees’ Aaron Judge (6-for-11, 4 HR) has done more in 2 games than this team has as a team in 3.

White Sox Betting Trends

• Chicago has scored just 2 runs in its last 2 games
• The White Sox’s last 3 losses to the Twins have been by 4 or more runs (8, 4, 6)
• The Under is 8-2-0 in the last 10 Chicago games overall
• Chicago was 10-42 vs the AL Central last season
• The White Sox were 31-92 vs RHPs last MLB season

Prediction

Two things stand out here, one emotional and the other statistical. Minnesota comes in having been swept by the Redbirds and in dire need of a win. There are four teams in the MLB without a victory as the weekend ends, and Minnesota is one of them (Braves, Tigers, Brewers). The statistical thing is the 12-1 series domination last season, meaning that the Twins will expect to beat the White Sox, who finished with the record for the most losses (121) in modern era history last season. With Paddock getting the pill, the visitors will have the pitching edge in what looks to be another low-scoring game at 35th and Shields. 

Final Pick

Minnesota Twins -1.5 -110