Seattle Mariners vs. San Francisco Giants Preview, Prediction & Odds | April 6, 2025

This Seattle Mariners vs. San Francisco Giants Preview will look at Game 3 on Sunday. In Game 1 on Friday, the Giants defeated the Mariners, 10-9 in 11 innings, while on Saturday in Game 2, San Francisco rolled to a 4-1 win. Last season, the Mariners won two of three games vs. San Francisco in The City By The Bay. Let’s examine the starting pitchers, the stats, the series, and general trends, and make a pick on this Interleague game.

Mariners vs. Giants Odds

Seattle Mariners at San Francisco Giants Game Details

• Game: Seattle Mariners at San Francisco Giants

• Date and Time: Sunday, April 6, 2025, 4:05 EDT/3:05 CDT/1:05 PDT

• Location: Oracle Park (Tifway 419 Bermuda Grass), San Francisco, California

Key Stats

Seattle Mariners

The Mariners (3-6, 0-2 on the Road) are scheduled to start RHP Brian Woo (1-0, 1.50 ERA, 0.83 WHIP in 2025) in this last game of this series. Woo has been effective vs the Giants in his career, going 1-0 with a 2.08 ERA and 14 strikeouts in 2 appearances. In Game 1 on Friday, Seattle pounded out 15 hits. Victor Robles (2 hits), Julio Rodriguez (3 hits, HR), Jorge Polanco (3 hits, HR, 4 RBI), and Luke Raley (2 hits) all had multi-hit games in the loss. With this being the third game of the series, expect both teams to be a little bit tired. The Mariners were 26-20 in Interleague play last season.

Mariners Betting Trends

• The Over is 5-4-1 in the last 10 in this series
• The Mariners are 2-6 in their last eight games 
• Woo went 6.0 IP, allowed three Hits, and one ER (HR) in a Win vs A’s
• The Mariners went 2-1 at San Francisco in 2023
• Seattle was 61-55 vs. RHP in the 2024 MLB Regular Season

San Francisco Giants

The Giants (7-1, 2-0 at Home) are scheduled to start RHP Jordan Hicks (1-0, 0.00 ERA, 0.50 WHIP in 2025) in this Home clash on Sunday. Like Woo, Hicks was very impressive in his first start of the MLB season, going 6.0 IP for the win, allowing 0 ER, just one hit and striking out six.

In Game 1 of this series, the Giants had three players with three hits: Lamonte Wade Jr. (3-6), Willy Adames (3-7, 3 RBI), Heliot Ramos (3-5), and Patrick Bailey (3-5). Ramos (.323), Wilmer Flores (4 HR, 10 RBI), Matt Chapman (.419 OBP), and Mike Yastremski (.300) have been the best at the plate for San Francisco so far this season. The Giants were 23-23 in Interleague play last year.

Giants Betting Trends

• San Francisco is 8-2 in its last 10 games dating back to last year
• The Giants have won 6 straight games
• The Over is 6-4-0 in the last 10 Giants games
• The Giants were 42-39 at Home last season
• San Francisco was 60-57 vs RHP in the 2024 MLB Regular Season

Prediction

The Giants are fighting in the best division in MLB, the NL West, where the defending World Series champion Dodgers (9-1), Padres (7-2), and Diamondbacks (5-4) are all feeding like piranhas on the early season MLB schedule.

With these two starters, expect runs to be scarce, but the lean is to the Giants’ bats over the Mariners (.198 BA, #24 in MLB), with the site and expectations playing a big part. The Home team with the positive Run Differential (+15) is the side pick over the Road team with a negative Run Differential (-12) in this Seattle Mariners vs. San Francisco Giants preview. Can you say sweep?

Final Pick

Giants -122