Detroit Lions @ San Francisco 49ers Preview, Prediction, & Odds | NFL Week 17, 2024

detroit lions

The Detroit Lions are heading to San Francisco to take on the 49ers on Monday Night Football. The Lions are coming off a big-time win on the road against the Chicago Bears, 34-17. Conversely, the 49ers are coming off a heartbreaking loss last week to the Miami Dolphins, 29-17. Detroit needs this win to stay ahead of the Minnesota Vikings and the Philadelphia Eagles to keep the number one seed in the NFC. Can the 49ers pull off the upset or will the Lions avenge their NFC Championship loss from last season? Let’s dive straight into this game and cook up a winning slip!

Detroit Lions vs. San Francsico 49ers Odds

Team Spread Total Money Line
Detroit Lions -3.5 (-105) Over 51.5 (-105) -194
San Francisco 49ers +3.5 (-115) Under 51.5 (-115) +162
**Odds Subject to Change**

Detroit Lions vs. San Francisco 49ers Match Details

  • Fixture: Detroit Lions @ San Francisco 49ers
  • Date and Time: December 30th, 2024 @ 8:15 PM EST 

Key Stats

Dec 12, 2024; Santa Clara, California, USA; San Francisco 49ers running back Isaac Guerendo (31) runs the ball against the Los Angeles Rams in the second quarter at Levi’s Stadium. Mandatory Credit: Cary Edmondson-Imagn Images

Detroit Lions

The Detroit Lions look like a team on a mission after destroying the Chicago Bears 34-17. Jared Goff was excellent by completing 23 of 32 passes for 336 yards and 3 touchdowns. Jameson Williams had his best game of the season by catching 5 passes for 143 yards and a touchdown.

Jahmyr Gibbs was dominant without his running mate David Montgomery by recording 154 yards from scrimmage, 23 carries for 109 yards, and 4 catches for 45 receiving yards. Amon-Ra St. Brown had a good game as well with 6 catches for 70 yards and a touchdown. This offense is one of the best in the NFL and will be a force in the playoffs.

The Lions’ defense has been hobbled by injuries all season long. However, they are ranked 7th in points allowed per game, 27th in passing yards allowed per game, 4th in rushing yards allowed per game, 6th in offensive touchdowns allowed, 23rd in sacks, and 9th in takeaways per game. Detroit has 19 players on injury reserve which is the most in the NFL. Other than that, they do not have any key questionable players leading into this game. Despite their injuries, this team is on fire, and seems like they are on a mission to avenge their NFC Championship loss last year to this 49ers team.

San Francisco 49ers

The San Francisco 49ers are coming off a tough loss last week on the road to the Miami Dolphins 29-17. Brock Purdy was decent in the loss. He completed 26 of 40 passes for 313 yards, 2 touchdowns, and an interception. Deebo Samuel Sr. had his best game of the season with 121 yards from scrimmage, 7 catches for 96 yards, 5 carries for 25 yards, and a receiving touchdown. George Kittle caught 8 passes for 106 yards. This team has also been riddled with injuries. With the loss last week, they are eliminated from the postseason and are ready for next season to begin.

The 49ers’ defense has been middle of the pack all season. They are ranked 19th in points allowed per game, 3rd in passing yards allowed per game, 15th in rushing yards allowed per game, 20th in offensive touchdowns allowed, 17th in sacks, and 17th in takeaways per game.

In terms of injuries, Trent Williams has already been ruled out in their last two games of the season. Isaac Guerendo is listed as questionable with an injury that kept him sidelined against the Dolphins. As mentioned earlier, this team just needs a long offseason to recover after back-to-back deep playoff runs to get their health right.

Prediction

The Detroit Lions are going to beat the brakes off the San Francisco 49ers in this game. If you want to take an alternate spread up to -6.5 at +130, that is still a great play. I think this is a bad matchup for the 49ers. We already saw Detroit avenge a loss they suffered last season and run up the score. Without Trent Williams, Brock Purdy will be under duress all game long. I expect the Detroit Lions to flex their muscles and lay it down against the 9ers. Jared Goff has played at an MVP level all season long and will continue moving forward. Detroit wins and covers the 3.5-point spread in this game.

Final Pick

Detroit Lions -3.5 (-105)

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