Louisville Cardinals vs. #11 Clemson Tigers Predictions and Odds | College Football Week 10

The 11th-ranked Clemson Tigers (6-1, 5-0 ACC will host the Louisville Cardinals (5-3, 3-2) this Saturday night in an ACC matchup. Clemson is coming off their off week, most recently beating the Virginia Cavaliers at home in Week 8 by a score of 48-31. Quarterback Cade Klubnik completed 23 of 35 passes for 308 yards, 3 touchdowns, and 1 interception. Running back Phil Mafah carried the ball 18 times for 78 yards and 2 touchdowns.

Louisville is coming off an away win against the Boston College Eagles in Week 9, beating them 31-27. Quarterback Tyler Shough completed 28 of 38 passes for 332 yards, 2 touchdowns, and 2 interceptions. Running back Isaac Brown carried the ball 18 times for 85 yards and 2 touchdowns.

Will Clemson continue to dominate in the ACC, or will Louisville put a dent in their ACC title hopes?

Louisville Cardinals vs. Clemson Tigers Odds

Team Spread Total Money Line
Louisville Cardinals +10.5

-110

Over 61

-112

+310
Clemson Tigers -10.5

-110

Under 61

-108

-395
**Odds Subject to Change**

Louisville Cardinals vs. Clemson Tigers Match Details

  • Fixture: Louisville Cardinals vs. Clemson Tigers
  • Date and Time: Saturday, November 2nd, 2024 at 7:30 PM ET
  • Location: Memorial Stadium, Clemson, South Carolina

Key Stats

Clemson Tigers QB Cade Klubnik
Sep 21, 2024; Clemson, South Carolina, USA; Clemson Tigers quarterback Cade Klubnik (2) runs for a first down against North Carolina State Wolfpack linebacker Caden Fordham (10) during the second quarter at Memorial Stadium. Mandatory Credit: Ken Ruinard-Imagn Images

Louisville Cardinals

The Louisville Cardinals enter the game 5-3, averaging 36.63 points per game this season. Isaac Brown leads the team in rushing, averaging 81.13 yards per game with 6 touchdowns. Quarterback Tyler Shough is averaging 293.5 passing yards per game and is completing 64.30% of his passes. So far this season, he has thrown 20 touchdowns and 5 interceptions.

Wide receiver Ja’Corey Brooks averages 99.86 receiving yards per game and has scored 8 touchdowns, while wide receiver Chris Bell is averaging 43.13 receiving yards per game and has 2 touchdowns. From a defensive standpoint, Louisville has 2 interceptions and 17 sacks. They are allowing 24.63 points per game.

Clemson Tigers

The Clemson Tigers enter 6-1, averaging 42.0 points per game this season. Running Back Phil Mafah leads the team in rushing, averaging 97.43 yards per game, and has 6 touchdowns. Quarterback Cade Klubnik is averaging 262.29 passing yards per game and is completing 66.70% of his passes. So far this season, Klubnik has thrown 20 touchdowns and 5 interceptions.

Wide receiver Antonio Williams is averaging 56.14 receiving yards per game and has scored 5 touchdowns. Jake Briningstool is averaging 46.71 receiving yards per game and has 4 touchdowns. Defensively, Clemson has 9 interceptions and 17 sacks. They are allowing 23.0 points per game.

Prediction

Clemson’s poor start in the season opener against Georgia is ancient history at this point in the season and since that loss, they have been nearly perfect. They have won their 5 ACC games by an average of 23.6 points per game. Further, their defense has generally played well and their opponents tend to do most of their scoring in garbage time when the Tigers are already of multiple scores.

As for Louisville, they have been somewhat inconsistent this season. Just this past week, the Cardinals were losing to Boston College 20-0 and then 27-10. They managed to come back to win that game, but Clemson will be a much tougher test. Simply put, Clemson has been dominant in ACC play, therefore we will be backing them to cover in this game on Saturday night.

Final Pick

Clemson Tigers -9.5 Alternate Spread (-133)

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